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You are here: Home / Archives for Elizabeth Szymanski

Elizabeth Szymanski

Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant

Elizabeth Szymanski · September 27, 2023 ·

Major Goals:  Annotate host exfoliated mucosal cell transcriptome, i.e., exfoliome, and fecal bacterial metagenome and metabolome profiles to identify biomarkers for preterm infants who have consistent tolerance to enteral feeding or who are diagnosed with feeding intolerance or ischemia.

Status of Support: Active

Project Number: RO1 HD112396-01

Name of PD/PI:  Multi-PI Chapkin/Donovan

Source of Support: NIH

Primary Place of Performance:  Texas A&M University, College Station, Texas; and University of Illinois-Champaign

Project/Proposal Start and End Date:  9/2023-8/2028

Total Award Amount (including Indirect Costs):  $3,958,957

Texas A&M University Faculty Affairs

Elizabeth Szymanski · September 14, 2023 ·

Congratulates Dr. Robert Chapkin for ASN Award

BREAKTHROUGH IN Wnt SIGNALING PUBLISHED!

Elizabeth Szymanski · August 23, 2023 ·

Breakthrough publication! Our recent paper in Nature Communications explains the novel structure-function mechanism by which cholesterol promotes colon cancer.  From a functional perspective, Wnt factors organize to form specialized plasma membrane (PM) domains. Dysregulation of Wnt domain structure can promote oncogenic Wnt signaling.  Here, we describe an intricate Wnt signaling-associated mechanism involving oncogenic truncated APC and the loss of PM cholesterol homeostasis, which alters the organization of Wnt signaling nanoassemblies (biomolecular condensates) and drives aberrant Wnt signaling and CRC tumorigenesis.  These highly significant findings are relevant to the nascent field of “membrane therapy”. 

Chapkin Lab Undergrad Researcher Receives Award for Poster Presentation

Elizabeth Szymanski · March 24, 2023 ·

Jennie P. Kim, a Nutritional Sciences major working on her Undergraduate Research Scholars Thesis in the Chapkin Lab (https://chapkinlab.tamu.edu) was recently awarded second place for her poster presentation in the Agricultural and Life Sciences category at the Texas A&M Student Research Week competition (https://srw.tamu.edu). Student Research Week is the largest student-run research symposium in the nation, spotlighting student research conducted at Texas A&M University. Currently, her research focuses on the effects of short-chain fatty acids (e.g., butyrate) on colonic organoid stem cell homeostasis and gene expression in high vs. normal glucose conditions. She plans to continue her involvement in undergraduate research in the Chapkin Lab and hopes to provide important contributions related to the expanding field of Precision Nutrition.

CPRIT – TREC GRANT FUNDED: Gene – environment – lifestyle interactions in cancer

Elizabeth Szymanski · February 15, 2023 ·

 

The Chapkin Lab is pleased to announce the award of a $6 million grant from Cancer Prevention and Research Institute of Texas – TREC funding to support research in “Gene – environment – lifestyle interactions in cancer”.   Dr. Robert Chapkin to serve as Deputy Director of the grant, Dr. Kenneth Ramos to serve as Director.  As part of this effort, we will establish a single-cell data science (SCDS) core at Texas A&M University in Bryan/College Station.  The SCDS core will serve as a Texas A&M Shared Resource Facility.  In terms of the complementary CPRIT grant and the SCDS core, Drs. James Cai and Yang Ni will serve as Director and co-Director, respectively.

https://www.cprit.texas.gov/grants-funded/grants/rp230204

 

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