DEVELOPMENT OF NOVEL EXFOLIATED CELL NONINVASIVE METHODOLOGY TO MONITOR HOST/MICROBE INTERACTIONS.
Early detection can be considered a method for prevention in the sense that it can prevent serious morbidity and mortality. To address this need, our team has identified novel early detection biomarkers, e.g., genomic signals, to classify/predict chronic inflammation, metabolic profiling, immune status, and gut barrier function on a molecular level in mouse models and humans. For this purpose, we mathematically model dynamical system behavior for the purpose of deriving therapeutic strategies to alter undesirable cellular behavior. Outcomes include the prediction of new nutraceutical / drug targets based on intracellular signaling pathways. Cutting edge applications include: (i) the influences of diet and the gut microbiome on host (using exfoliated cells) epigenetic modulation in neonates, and (ii) simultaneous analysis of the multivariate structure between the gut metatranscriptome and host transcriptome using noninvasive methodologies.
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