Major Goals: We will determine the anticarcinogenic activities of bis-indole derived (CDIMs) NR4A1 ligands in mouse and human cells with a particular focus on the regulation of the checkpoint inhibitor gene PD-L1.
*Status of Support: Active
Project Number: NIH RO1 CA269580-01A1
Name of PD/PI: Safe; Chapkin, Role: co-investigator
*Source of Support: NIH
*Primary Place of Performance: Texas A&M University, College Station, Texas
Project/Proposal Start and End Date: 1/2023-12/2026
* Total Award Amount (including Indirect Costs): $2,767,394 ($1,111,558 RSC)