Publications

Click on the articles below. More publications by Dr. Chapkin and the Chapkin Lab Team can be found on PubMed.

• Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands
  May 7, 2025 by Lei Zhang
  Bis-indole-derived compounds including 1,1-bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) analogs bind both orphan nuclear receptors 4A1 (NR4A1) and NR4A2, and DIM-3,5 compounds act as […]
• Single-cell transcriptomics reveals that human milk feeding shapes neonatal immune cell interleukin signaling pathways in a nonrandomized clinical trial
  April 28, 2025 by Michael L Salinas
  CONCLUSIONS: These findings suggest that human milk downregulates peripheral immune cell cytokine transcriptional signatures linked to allergic inflammation and infection […]
• A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells
  March 26, 2025 by Ebru Ece Gülşan
  Gut microbial metabolism of dietary flavonoids leads to a diverse array of bioactive products that are closely associated with human […]
• Targeting polyunsaturated fatty acids desaturase FADS1 inhibits renal cancer growth via ATF3-mediated ER stress response
  March 23, 2025 by Gioia Heravi
  CONCLUSION: Our findings suggest that PUFA desaturation is crucial for rescuing cancer cells from persistent ER stress, supporting FADS1 as […]
• Exploring cell-to-cell variability and functional insights through differentially variable gene analysis
  March 21, 2025 by Victoria Gatlin
  Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular variability by capturing gene expression profiles of individual cells. The […]
• Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis
  March 11, 2025 by Amanuel Hailemariam
  Polyfluoroalkyl substances (PFAS) are widely used industrial compounds that have been identified as contaminants in almost every component of the […]
• Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains
  December 22, 2024 by Eunjoo Kim
  Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the […]
• Graphical Dirichlet Process for Clustering Non-Exchangeable Grouped Data
  December 18, 2024 by Arhit Chakrabarti
  We consider the problem of clustering grouped data with possibly non-exchangeable groups whose dependencies can be characterized by a known […]
• 1,4-dihydroxy-2-naphthoic acid prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced motor function deficits
  December 11, 2024 by Caitlin A Madison
  Parkinson's disease (PD), characterized by death of dopaminergic neurons in the substantia nigra, is the second most prevalent progressive neurodegenerative […]
• Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation
  September 28, 2024 by Erika L Garcia-Villatoro
  Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes […]
• TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype
  June 5, 2024 by Roanna A Debler
  The etiology of major depressive disorder (MDD) remains poorly understood. Our previous studies suggest a role for the aryl hydrocarbon […]
• Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response
  April 8, 2024 by Gioia Heravi
  Monounsaturated fatty acids (MUFAs) play a pivotal role in maintaining endoplasmic reticulum (ER) homeostasis, an emerging hallmark of cancer. However, […]
• A Unified Bayesian Framework for Bi-overlapping-Clustering Multi-omics Data via Sparse Matrix Factorization
  January 5, 2024 by Fangting Zhou
  The advances of modern sequencing techniques have generated an unprecedented amount of multi-omics data which provide great opportunities to quantitatively […]
• Interfacial Electromigration for Analysis of Biofluid Lipids in Small Volumes
  December 5, 2023 by Madison E Edwards
  Lipids are important biomarkers within the field of disease diagnostics and can serve as indicators of disease progression and predictors […]
• Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion
  October 17, 2023 by Kumaravel Mohankumar
  There is evidence that the orphan nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in exhausted CD8 + T cells and […]