Publications

Click on the articles below. More publications by Dr. Chapkin and the Chapkin Lab Team can be found on PubMed.

• Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains
  December 22, 2024 by Eunjoo Kim
  Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the […]
• Graphical Dirichlet Process for Clustering Non-Exchangeable Grouped Data
  December 18, 2024 by Arhit Chakrabarti
  We consider the problem of clustering grouped data with possibly non-exchangeable groups whose dependencies can be characterized by a known […]
• 1,4-dihydroxy-2-naphthoic acid prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced motor function deficits
  December 11, 2024 by Caitlin A Madison
  Parkinson's disease (PD), characterized by death of dopaminergic neurons in the substantia nigra, is the second most prevalent progressive neurodegenerative […]
• Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation
  September 28, 2024 by Erika L Garcia-Villatoro
  Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes […]
• TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype
  June 5, 2024 by Roanna A Debler
  The etiology of major depressive disorder (MDD) remains poorly understood. Our previous studies suggest a role for the aryl hydrocarbon […]
• Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response
  April 8, 2024 by Gioia Heravi
  Monounsaturated fatty acids (MUFAs) play a pivotal role in maintaining endoplasmic reticulum (ER) homeostasis, an emerging hallmark of cancer. However, […]
• A Unified Bayesian Framework for Bi-overlapping-Clustering Multi-omics Data via Sparse Matrix Factorization
  January 5, 2024 by Fangting Zhou
  The advances of modern sequencing techniques have generated an unprecedented amount of multi-omics data which provide great opportunities to quantitatively […]
• Interfacial Electromigration for Analysis of Biofluid Lipids in Small Volumes
  December 5, 2023 by Madison E Edwards
  Lipids are important biomarkers within the field of disease diagnostics and can serve as indicators of disease progression and predictors […]
• Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion
  October 17, 2023 by Kumaravel Mohankumar
  There is evidence that the orphan nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in exhausted CD8 + T cells and […]
• Fate and distribution of orally-ingested CeO₂-nanoparticles based on a mouse model: Implication for human health
  October 13, 2023 by Xingmao Ma
  The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans […]
• Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach
  September 26, 2023 by Alexander Roitershtein
  We study a discrete-time multi-type Wright-Fisher population process. The mean-field dynamics of the stochastic process is induced by a general […]
• Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin
  July 19, 2023 by Alfredo Erazo-Oliveras
  Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that […]
• Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks
  May 29, 2023 by Yongjian Yang
  In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell […]
• Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
  May 13, 2023 by Miok Lee
  It was recently reported that the hydroxyflavones quercetin and kaempferol bind the orphan nuclear receptor 4A1 (NR4A1, Nur77) and act […]
• Selective aryl hydrocarbon receptor modulators can act as antidepressants in obese female mice
  April 21, 2023 by Roanna A Debler
  CONCLUSIONS: DHNA protected against UCMS-induced depression-like behaviors in HFD-fed female mice. DHNA neither improved nor worsened UCMS-induced impairment of spatial […]