Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. The lab has been continuously funded by the National Institutes of Health (NIH) for the past 36 years.
Most Recent ASN Achievement : Dr. Chapkin named American Society for Nutrition 2024 Fellow
Most Recent NIH Award: Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
Presentation: “Targeting Plasma Membrane Spatial Dynamics to Suppress Aberrant Wnt Signaling”
Chapkin Lab is proud to recognize Bailee McEwan’s Award for Student Research Week: 2nd Overall for Oral Presentation. She presented “Effects of p53 loss of function on plasma membrane structure, organization, dynamics, and Wnt signaling”. Bailee comes to our lab with an interest in oncology and pursuing a career in medicine.
Chapkin Lab is proud to recognize Jennie P. Kim (undergraduate trainee in nutrition). Jennie was awarded the College of Agriculture and Life Sciences Senior Merit Award for her work assessing the chemoprotective effects of short chain fatty acids on mouse colonic growth and histone deacetylase activity.
8th Annual Postdoctoral Research Symposium Distinguished Postdoctoral Poster Presentation
First Place Award presented to Dr. Vanessa Montoya-Uribe
Assessing ‘field cancerization’ in a colonic stem cell mismatch repair in vivo model of Lynch syndrome
Dr. Montoya-Uribe’s research focuses on elucidating the mechanisms underlying the pathogenesis of Lynch syndrome in response to pro-inflammatory diets. Lynch Syndrome is one of the most common causes of hereditary colorectal cancer (CRC) that affects approximately 30 million people around the world. Lynch Syndrome patients have germline mutations in genes that regulate cellular DNA mismatch repair (MMR) in the body. However, the mechanisms underlying the pathogenesis of CRC in Lynch Syndrome have not been elucidated. Thus, Dr. Montoya-Uribe tracked the fate of DNA mismatch repair deficient-colonic stem cells lineages in mice fed a high-fat diet during the initial stages of CRC. Her novel findings demonstrate for the first time that MMR-deficient colonic stem cells have a selective advantage (compared to normal wildtype) and clonally expand over time. We propose that MMR-deficient crypts drive cancer initiation.
TEXAS REGIONAL CENTER OF EXCELLENCE IN CANCER RESEARCH – TREC
TREC EVENTS
- April 4, 2025: 3rd Annual TREC Symposium @ Texas A&M Hotel and Conference Center
- Keynote Speaker: Dr. Toby Lawrence
- Ontogeny and function of tumor-associated macrophages
- 1pm – 6:15pm
- Keynote Speaker: Dr. Toby Lawrence
Previous Event Information
RECENTLY PUBLISHED:
- American Society for Nutrition Foundation Announces Class of 2024 Fellows
April 1, 2024 by ASN Staff ASN’s Class of 2024… Read more: American Society for Nutrition Foundation Announces Class of 2024 Fellows - NEWS
- Texas A&M AgriLife researcher receives $4 million grant to study feeding intolerance in preterm infants
Novel noninvasive method allows for precise diagnosis of feeding intolerance… Read more: Texas A&M AgriLife researcher receives $4 million grant to study feeding intolerance in preterm infants - Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
Major Goals: Annotate host exfoliated mucosal cell transcriptome, i.e., exfoliome,… Read more: Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant - Texas A&M University Faculty Affairs
Congratulates Dr. Robert Chapkin for ASN Award
FOLLOW US ON X (formerly known as Twitter) @ChapkinLab
Congrats to the 2023 Mary Swartz Rose Investigator Awardees, shown here at the @nutritionorg #Nutrition2023 event in Boston yesterday! These awards are given for outstanding #research on the #safety & efficacy of bioactive compounds for human #health. https://t.co/RtGTwMQRrN pic.twitter.com/phLIP6JzyA— CRN (@CRN_Supplements) July 24, 2023
Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin https://t.co/wxCT8liokp— The Chapkin Lab (@ChapkinLab) August 23, 2023