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Chapkin Lab

  • People
    • Dr. Chapkin Biography
    • CHAPKIN LAB RESEARCH STAFF
      • Meet Dr. Laurie Davidson
      • Meet Dr. Alfredo Erazo-Oliveras
      • Meet Dr. Yang-Yi Fan
      • Meet Jennifer Goldsby
      • Meet Dr. Monica Muñoz Vega
      • Meet Jaileen Rivera-Rodriguez
      • Meet Kristen Frederick
      • Meet Lexi Poston
    • CHAPKIN LAB POST-DOCTORAL RESEARCHERS
      • Meet Dr. Michael Salinas
      • Meet Dr. Vanessa Montoya Uribe
      • Meet Dr. Selim Romero
      • Meet Dr. Pritam Dey
    • CHAPKIN LAB GRADUATE STUDENTS
      • Meet Destiny Mullens
    • CHAPKIN LAB UNDERGRADUATE STUDENTS
      • Meet Jennie P. Kim
      • Meet Bailee McEwan
    • CHAPKIN LAB ADMINISTRATOR
      • Meet Ms. Elizabeth Toole Szymanski
  • News
  • Research
    • NR4A1 & Arylhydrocarbon Receptor Biology
    • Gut Stem Cell Biology
    • Host-Microbe Interactions in the Human Gut
    • Membrane Therapy
  • Publications
  • CPRIT/TREC Single Cell Core
    • Single Cell Data Science Core & Chapkin Lab
    • Events with the SCDS Core Team
    • Events Sponsored by Texas A&M University Regional Center of Excellence in Cancer Research (TREC)
    • Single Cell Data Science Core – Recently Published Research
  • Lab Funding
    • Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
    • Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling
    • NR4A1 antagonists inhibit colorectal cancer growth and enhance immune surveillance
    • Bayesian differential causal network and clustering methods for single-cell data
    • The selective advantage of mismatch repair loss in colonic stem cells
    • Mediterranean diet and weight loss: Targeting the bile acid/gut microbiome axis to reduce colorectal cancer risk
    • Dietary and microbial predictors of childhood obesity risk
    • Diet and the colonic exfoliome: A novel, non-invasive approach to testing interventions in humans
    • Gene – environment – lifestyle interactions in cancer
  • William W. Allen Endowed Chair
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Opportunities

1. Post-Doc Investigator in Biostatistics and Single Cell Multi-omic Data Science, click HERE.

2. Microscopist position available, click HERE.

3. Post-Doctoral lab position available, click HERE.

4. Research Associate lab position available, click HERE.

 

Dr. Robert S. Chapkin – Distinguished Professor and National Cancer Institute R35 Outstanding Investigator Awardee, leads the Program in Integrative Nutrition & Complex Diseases at Texas A&M University. Work in the Chapkin lab focuses on dietary prevention of colon cancer and chronic inflammatory diseases. The central goal is to (1) understand cancer chemoprevention at the single cell level, and (2) test membrane targeted therapeutics in combination with dietary / microbial countermeasures to the “Western diet” to more effectively improve gut health and reduce colon cancer and chronic inflammatory diseases. Since diet influences gut microbial composition and metabolite production, to unravel the interrelationships between gut health and the structure of the gut ecosystem, we are in the process of evaluating (using transgenic mice, fruit fly models, and humans) how gut microbes modulate intestinal stem cells (the origin of cancer). As part of this endeavor, we have developed novel noninvasive Systems Biology-based methodologies to model the dynamic relationship between diet and gut microbe-derived metabolites which modulate the cellular organization of the intestine, e.g., stem cell niche.

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