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Home > Archives for crystal.schibler

New NIH Grant Awarded

9Oct

Chapkin Lab  is pleased to announce the funding of a new grant!
Attempts to target aberrant Wnt signaling using drugs still face multiple hurdles due to poor tumor cell targeting, negative side effects associated with required long-term treatments and a poor understanding of the mechanisms of action.  Consequently, there is an urgent need to further assess non-toxic Wnt targeted therapeutic approaches.  This recently funded NIH grant proposal seeks to develop novel membrane targeted therapeutic approaches to abate abnormal Wnt signaling in the colon.

New Stem Cell Paper Published in EMBO Journal

29Sep

We are pleased to announce that our paper on, “Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells” has been published in the EMBO Journal and can now be accessed online.

Authors include: Huajun Han, Laurie A Davidson, Yang‐Yi Fan, Jennifer S Goldsby, Grace Yoon, Un‐Ho Jin, Gus A Wright, Kerstin K Landrock, Bradley R Weeks, Rachel C Wright, Clinton D Allred, Arul Jayaraman, Ivan Ivanov, Jatin Roper, Stephen H Safe, Robert S Chapkin

You can view the abstract at the link below:
https://www.embopress.org/doi/epdf/10.15252/embj.2019104319

 

 

Chapkin Lab receives a Cancer Prevention and Research Institute of Texas (CPRIT) High Impact High Risk Grant

7Sep

Chapkin Lab  is pleased to announce that Dr. Robert Chapkin was awarded a $250,000 grant from The Cancer Prevention and Research Institute of Texas (CPRIT). These funds will support the “Targeting Plasma Membrane Spatial Dynamics to Suppress Obesity-Induced Colon Cancer” project.

Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation.

CPRIT awards annual grants through a competitive application and review process. For more on CPRIT awards at Texas A&M University, please view here.

Promotions in the Chapkin Lab

26Aug

Alfredo Erazo-Oliveras

Dr. Alfredo Erazo- Oliveras

The Chapkin Lab is pleased to announce the promotion of Dr . Alfredo Erazo-Oliveras and Dr.  Xiaoli Wang from Post-Doctoral Researchers to Assistant Research Scientists.

Alfredo has been with the Chapkin Lab for 4 years and has frequently been recognized for outstanding achievement. Alfredo’s main research focus is to establish the role of oncogenic APC on the dysregulation of cellular plasma membrane physical-chemical properties/homeostatic status and induction of aberrant Wnt signaling in the colon.

Dr. Xiaoli Wang

Dr. Xiaoli Wang

Xiaoli has been with the Chapkin Lab for just under a year and has quickly proven to be an asset to the team.  Xiaoli’s research is focusing on the study of plasma membrane protein interactions (plasma membrane spatial dynamics-nanoclustering) using complementary fluorescence microscopy techniques. By understanding the mechanism behind those biological processes, her goal is to facilitate the development of membrane-targeted therapies.
Please join us in congratulating Alfredo & Xiaoli on their promotions!

Salinas Selected as Finalist for ASN Nutrition 2020

10Jun

Michael Salinas has been named an Emerging Leaders in Nutrition Science Finalist, and a Graduate Student Research Award Finalist, a program of the American Society for Nutrition (ASN) to recognize the highest quality research presented by students and young investigators at NUTRITION 2020 LIVE ONLINE.

More than 1,000 abstracts were submitted by students and postdoctoral fellows and the Emerging Leaders in Nutrition Science program aims to recognize the top 15% highest scoring abstracts as finalists.  Abstracts were rated by more than 500 nutrition scientists.

Mr. Salinas’s abstract for NUTRITION 2020 LIVE ONLINE is titled
High-Fat Diet-Induced Obesity Modulates Colonic Lgr5+ Stem Cell Homeostasis by Dysregulating Plasma Membrane Organization.

“Through this activity, the American Society for Nutrition celebrates the achievements of our rising stars,” stated Richard Mattes, PhD, MPH, RD, President, American Society for Nutrition.   “The Society looks forward to watching their future contributions to advance our understanding of nutrition science and practice.”

For a full list of Emerging Leaders in Nutrition Science Finalists, visit https://meeting.nutrition.org/2020awards/#abstract2020.

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Chapkin Laboratory
Lab Phone: 979-845-0448
Office Phone: 979-845-2142
E-mail: r-chapkin@tamu.edu

 

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Categories

Have a 2nd Cup of Coffee

Have a second cup: Coffee provides health benefits Review paper outlines Texas A&M research on protective effects of coffee APRIL 27, 2023 Having that second cup may actually be good for coffee drinkers, according to a discussion of coffee’s preventive and therapeutic benefits to human health in a recent review paper by Texas A&M University researchers. The… Read More →

Texas A&M receives $6 million to create Center of Excellence in Cancer

https://vitalrecord.tamhsc.edu/texas-am-receives-6-million-to-create-center-of-excellence-in-cancer/ Texas A&M receives $6 million to create Center of Excellence in Cancer Five-year grant from the Cancer Prevention and Research Institute of Texas will support infrastructure to investigate and advance cancer prevention and care April 4, 2023 Jennifer Cain Texas A&M University Health Science Center (Texas A&M Health) has been awarded a five-year, $6… Read More →

Chapkin Lab Undergrad Researcher Receives Award for Poster Presentation

Jennie P. Kim, a Nutritional Sciences major working on her Undergraduate Research Scholars Thesis in the Chapkin Lab (https://chapkinlab.tamu.edu) was recently awarded second place for her poster presentation in the Agricultural and Life Sciences category at the Texas A&M Student Research Week competition (https://srw.tamu.edu). Student Research Week is the largest student-run research symposium in the… Read More →

CPRIT – TREC GRANT FUNDED: Gene – environment – lifestyle interactions in cancer

  The Chapkin Lab is pleased to announce the award of a $6 million grant from Cancer Prevention and Research Institute of Texas – TREC funding to support research in “Gene – environment – lifestyle interactions in cancer”.   Dr. Robert Chapkin to serve as Deputy Director of the grant, Dr. Kenneth Ramos to serve as… Read More →

TEXAS A&M RESEARCHERS TO FURTHER DEVELOP UNIQUE CANCER DRUG WITH $2.3M NIH GRANT

Drs. Robert Chapkin, Gus Wright, James Cai, and Stephen Safe received a new NIH grant to perform a single cell multi-omic analysis of the colon tumor microenvironment to probe the mechanistic underpinnings of NR4A1-dependent modulation of T-cell exhaustion. Story by Jennifer Gauntt, VMBS Communications February 1, 2023 Preliminary data indicate that the compounds developed in… Read More →

Reappointed holder of the William W. Allen Chair in Nutrition & Chronic Disease Prevention in the Department of Nutrition

Congratulations! Dr. Robert S. Chapkin has been reappointed as the holder of the William W. Allen Chair in Nutrition & Chronic Disease Prevention in the Department of Nutrition for a second 5-year term from December 1, 2022 to November 30, 2027.    As the holder of the William W. Allen Chair in Nutrition since December… Read More →

$1.19 million grant will leverage single-cell sequencing technology: National Institutes of Health-funded project will help with cancer diagnosis, treatment, prevention

  The Texas A&M University System has received a $1.19 million grant from the National Institutes of Health, NIH, for a multidisciplinary collaboration to study the intricate connections between genomics, nutrition and health. Understanding these connections will help in the diagnosis and treatment of cancer and other diseases. Yang Ni, Ph.D., an assistant professor in the College of… Read More →

Personalized Nutrition

Dr. Chapkin presents an invited webinar on “Personalized nutrition using microbial metabolite phenotype to stratify participants”.  This presentation also features a discussion on host exfoliomics (host mRNAs isolated from the fecal stream) that reveal the effects of dietary fiber in a clinical trial.  

Texas A&M AgriLife Research recognizes outstanding achievers

Research Scientist of the Year Award: Robert Chapkin, Ph.D Texas A&M AgriLife Research Professor Robert Chapkin, Ph.D., College Station, has made outstanding contributions to the areas of precision nutrition and stem cell biology, cancer chemoprevention and the development of noninvasive predictive biomarkers. Chapkin carries the title of Distinguished Professor in the Texas A&M University Department of… Read More →

Researchers target cell membranes for cancer research

“We are pleased to announce the publication of our recent paper on membrane therapy.  The paper is highlighted in the American Society of Biochemistry & Molecular Biology (ASBMB) Today and can now be accessed online”. Fuentes JLR 2021,   Supplemental Material . “You can read the article about our recent paper in the Journal of Lipid… Read More →

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