Major Goals: We will determine the anticarcinogenic activities of bis-indole derived (CDIMs) NR4A1 ligands in mouse and human cells with a particular focus on the regulation of the checkpoint inhibitor gene PD-L1.

*Status of Support: Active

Project Number: NIH RO1 CA269580-01A1

Name of PD/PI:  Safe; Chapkin, Role: co-investigator

*Source of Support: NIH

*Primary Place of Performance:  Texas A&M University, College Station, Texas

Project/Proposal Start and End Date: 1/2023-12/2026

* Total Award Amount (including Indirect Costs):  $2,767,394 ($1,111,558 RSC)