Major Goals:  We hypothesize that colonic stem cells (CSCs) that lose MMR function will gain a selective advantage over neighboring MMR-proficient cells, particularly in a mutagenic environment such as may be found in the colon.  The proposed aims utilize novel approaches to study the mechanism by which loss of MMR function contributes to tumorigenesis providing information that may help explain disease penetrance while guiding the diagnosis, prevention and treatment of Lynch Syndrome-associated cancers.

*Status of Support: Active

Project Number: NIH RO1 CA245514

Name of PD/PI:  Heinen; Chapkin, Role: co-investigator

*Source of Support: NIH

*Primary Place of Performance:  Texas A&M University, College Station, Texas

Project/Proposal Start and End Date: 9/2021-8/2026

* Total Award Amount (including Indirect Costs):  $2,836,970 ($1,229,185 RSC)