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    • Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
    • Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling
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    • Bayesian differential causal network and clustering methods for single-cell data
    • The selective advantage of mismatch repair loss in colonic stem cells
    • Mediterranean diet and weight loss: Targeting the bile acid/gut microbiome axis to reduce colorectal cancer risk
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Recent Publication in Cancer Research

crystal.schibler · July 30, 2018 ·

Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition

Natividad R. Fuentes1,2, Mohamed Mlih3, Rola Barhoumi4, Yang-Yi Fan1, Paul Hardin5, Trevor J. Steele6, Spencer Behmer6, Ian A. Prior7,
Jason Karpac3, and Robert S. Chapkin1,8

Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that Ras nanocluster proteolipid composition could represent a novel target for future chemoprevention interventions. Read More….

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