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Chapkin Lab

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    • Dr. Chapkin Biography
    • CHAPKIN LAB RESEARCH STAFF
      • Meet Dr. Laurie Davidson
      • Meet Dr. Alfredo Erazo-Oliveras
      • Meet Dr. Yang-Yi Fan
      • Meet Jennifer Goldsby
      • Meet Dr. Monica Muñoz Vega
      • Meet Jaileen Rivera-Rodriguez
      • Meet Kristen Frederick
      • Meet Lexi Poston
    • CHAPKIN LAB POST-DOCTORAL RESEARCHERS
      • Meet Dr. Michael Salinas
      • Meet Dr. Vanessa Montoya Uribe
      • Meet Dr. Selim Romero
      • Meet Dr. Pritam Dey
    • CHAPKIN LAB GRADUATE STUDENTS
      • Meet Destiny Mullens
    • CHAPKIN LAB UNDERGRADUATE STUDENTS
      • Meet Jennie P. Kim
      • Meet Bailee McEwan
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      • Meet Ms. Elizabeth Toole Szymanski
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    • NR4A1 & Arylhydrocarbon Receptor Biology
    • Gut Stem Cell Biology
    • Host-Microbe Interactions in the Human Gut
    • Membrane Therapy
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    • Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
    • Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling
    • NR4A1 antagonists inhibit colorectal cancer growth and enhance immune surveillance
    • Bayesian differential causal network and clustering methods for single-cell data
    • The selective advantage of mismatch repair loss in colonic stem cells
    • Mediterranean diet and weight loss: Targeting the bile acid/gut microbiome axis to reduce colorectal cancer risk
    • Dietary and microbial predictors of childhood obesity risk
    • Diet and the colonic exfoliome: A novel, non-invasive approach to testing interventions in humans
    • Gene – environment – lifestyle interactions in cancer
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Research

Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation.

Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. 

As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.  Work in the lab related to intestinal “phenotypic flexibility” falls into four specific areas:

Dr. Alfredo Erazo-Oliveras
Host-Microbe

Host-Microbe Crosstalk

AhR

Arylhydrocarbon Receptor Biology

Membrane Therapy

Membrane Therapy

Diet/Microbial Bioactive

Gut Stem Cell Biology

Download our Research Summary

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