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Chapkin Lab

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    • Dr. Chapkin Biography
    • CHAPKIN LAB RESEARCH STAFF
      • Meet Dr. Laurie Davidson
      • Meet Dr. Alfredo Erazo-Oliveras
      • Meet Dr. Yang-Yi Fan
      • Meet Jennifer Goldsby
      • Meet Dr. Monica Muñoz Vega
      • Meet Jaileen Rivera-Rodriguez
      • Meet Kristen Frederick
      • Meet Lexi Poston
    • CHAPKIN LAB POST-DOCTORAL RESEARCHERS
      • Meet Dr. Michael Salinas
      • Meet Dr. Vanessa Montoya Uribe
      • Meet Dr. Selim Romero
      • Meet Dr. Pritam Dey
    • CHAPKIN LAB GRADUATE STUDENTS
      • Meet Destiny Mullens
    • CHAPKIN LAB UNDERGRADUATE STUDENTS
      • Meet Jennie P. Kim
      • Meet Bailee McEwan
    • CHAPKIN LAB ADMINISTRATOR
      • Meet Ms. Elizabeth Toole Szymanski
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    • NR4A1 & Arylhydrocarbon Receptor Biology
    • Gut Stem Cell Biology
    • Host-Microbe Interactions in the Human Gut
    • Membrane Therapy
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  • CPRIT/TREC Single Cell Core
    • Single Cell Data Science Core & Chapkin Lab
    • Events with the SCDS Core Team
    • Events Sponsored by Texas A&M University Regional Center of Excellence in Cancer Research (TREC)
    • Single Cell Data Science Core – Recently Published Research
  • Lab Funding
    • Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
    • Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling
    • NR4A1 antagonists inhibit colorectal cancer growth and enhance immune surveillance
    • Bayesian differential causal network and clustering methods for single-cell data
    • The selective advantage of mismatch repair loss in colonic stem cells
    • Mediterranean diet and weight loss: Targeting the bile acid/gut microbiome axis to reduce colorectal cancer risk
    • Dietary and microbial predictors of childhood obesity risk
    • Diet and the colonic exfoliome: A novel, non-invasive approach to testing interventions in humans
    • Gene – environment – lifestyle interactions in cancer
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Mentoring Philosophy

Transparency, honesty and fairness are central tenets of his training and mentoring philosophy. Dr. Chapkin embraces both scientific rigor and transparency in accordance with NIH ethics guidelines. For example, all his trainees are counseled in the four areas deemed important for enhancing rigor and transparency that applies to the full spectrum of research, basic to clinical. Specifically:

  1. The scientific premise forming the basis of the proposed research.
  2. Rigorous experimental design and reporting of unbiased scientific results.
  3. Consideration of relevant biological variables.
  4. Authentication of key biological and chemical resources.

It is emphasized repeatedly that Dr. Chapkin expects all trainees will achieve robust and unbiased results. All his trainees participate in program-sponsored seminars and an ethics class offered by several of the Departments with interest in Cancer Prevention. In addition, since he is a member of an NCI-funded T32 post-doctoral training program (T32-CA090301, formerly R25-CA090301) in Nutrition, Biostatistics & Bioinformatics (http://www.stat.tamu.edu/train/), his lab members have the opportunity to interact with statistically oriented trainees (Biostatisticians, Statisticians, Engineers, Mathematicians, Computer Scientists, etc.) who are developing new statistical and computational methods that are tailored to the biology of Nutrition and Cancer.

Transparency and reproducibility in publishing
In this video, the American Society for Biochemistry and Molecular Biology’s data integrity manager, Kaoru Sakabe, covers common issues that authors face while preparing manuscripts and the consequences of not following best practices.

Sakabe gave the talk as part of the Johns Hopkins School of Medicine’s Research Integrity Colloquia in January.

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